View abstract. Efficacy of Lactobacillus-supplemented triple therapy for Helicobacter pylori infection in children: a meta-analysis of randomized controlled trials. 2013;16(3):347-55. Most research shows that taking probiotic products containing lactobacillus strains helps prevent diarrhea caused by antibiotics in adults and children. Adjuvant probiotics improve the eradication effect of triple therapy for Helicobacter pylori infection. 2010;157(4):598-602. The effect of Lactobacillus GG on acute diarrheal illness in the pediatric emergency department. Probiotic prophylaxis of ventilator-associated pneumonia: a blinded, randomized, controlled trial. McFarland LV. JAMA Pediatr. 2014;40(2):200-7. Some research shows that taking lactobacillus does not reduce fat or weight in most obese adults. Nutr Cancer 1999;35:153-9. Taking a drink containing one strain of lactobacillus 5 days weekly for 8 weeks reduces the incidence of the flu in schoolchildren during flu season. Gorbach SL. View abstract. A randomized trial of Lactobacillus plantarum CJLP133 for the treatment of atopic dermatitis. Pediatr Infect Dis J 1997;16:1103-7. View abstract. L. crispatus, L. jensenii, L. iners, L. gasseri (and possibly L. vaginalis), as assessed through cultivation-dependent and Efficacy of Lactobacillus GG in prevention of nosocomial diarrhea in infants. have indicated that the activity of bacteriocins is favored by low pH. Treatment of irritable bowel syndrome with Lacteol Fort: a randomized, double-blind, cross-over trial. J Allergy Clin Immunol 2003;111:389-95. Pierce A. Mohseni AH, Taghinezhad-S S, Keyvani H, Ghobadi N. Comparison of Acyclovir and Multistrain Lactobacillus brevis in Women with Recurrent Genital Herpes Infections: a Double-Blind, Randomized, Controlled Study. View abstract. View abstract. Research in trained athletes shows that taking lactobacillus probiotics does not reduce the risk of developing a airway infection. Effect of a probiotic preparation (VSL#3) on induction and maintenance of remission in children with ulcerative colitis. Med Sci Monit 2004;10:PI126-31. View abstract. Efficacy of a standardized extract of Matricariae chamomilla L., Melissa officinalis L. and tyndallized Lactobacillus acidophilus (HA122) in infantile colic: an open randomized controlled trial. Mustapha A, Jiang T, Savaiano DA. J Cutan Med Surg. 2013;89(4):381-7. J Pediatr 2017;186:82-6. View abstract. View abstract. Role of Small Intestinal Bacterial Overgrowth in Functional Gastrointestinal Disorders. Cremonini F, Di Caro S, Covino M, et al. Nutrition. [42] Pregnancy alters the microbiota with a reduction in species/genus diversity. Multicenter Trial of a Combination Probiotic for Children with Gastroenteritis. Does probiotic supplementation aid weight loss? Francavilla R, Polimeno L, Demichina A, Maurogiovanni G, Principi B, Scaccianoce G, Ierardi E, Russo F, Riezzo G, Di Leo A, Cavallo L, Francavilla A, Versalovic J. Lactobacillus reuteri strain combination in Helicobacter pylori infection: a randomized, double-blind, placebo-controlled study. World J Gastroenterol 2012;18(43):6302-7. View abstract. View abstract. Probiotics in prevention of IgE-associated eczema: a double-blind, randomized, placebo-controlled trial. Rautio M, Jousimies-Somer H, Kauma H, et al. Gleeson M, Bishop NC, Struszczak L. Effects of Lactobacillus casei Shirota ingestion on common cold infection and herpes virus antibodies in endurance athletes: a placebo-controlled, randomized trial. Probiotics are effective at preventing Clostridium difficile-associated diarrhea: a systematic review and meta-analysis. J Allergy Clin Immunol. Lü M, Yu S, Deng J, et al. Strus, M., M. Malinowska, and P. B. Heczko. 2020;11(1):2533. A placebo-controlled trial of Lactobacillus GG to prevent diarrhea in undernourished Peruvian children. View abstract. 47:41–46. 2013;50(4):377-81. Clin Exp Allergy 1998;28:1474-9. Int J Clin Pract 1999;53:179-84. View abstract. Morrow LE, Kollef MH, Casale TB. 2015;15:115. The amount and type of bacteria present have significant implications for a woman's overall health. Gill HS, Rutherfurd KJ. Choi CH, Chang SK. [37], The effect of tampon use on vaginal flora is debated, but application of tampons appears not to significantly modify the balance of bacterial presence. Probiotics for the prevention and treatment of antibiotic-associated diarrhea: a systematic review and meta-analysis. Blaabjerg S, Artzi DM, Aabenhus R. Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Outpatients-A Systematic Review and Meta-Analysis. Effects of Lactobacillus casei supplementation on disease activity and inflammatory cytokines in rheumatoid arthritis patients: a randomized double-blind clinical trial. PLoS One 2012;7(4):e34540. View abstract. Nutrition. View abstract. Eur J Gastroenterol Hepatol 2001;13:25–9. Wickens K, Barthow C, Mitchell EA, et al. But some individual studies disagree. View abstract. J Pediatr 1999;135:564-8. J Clin Periodontol. Wu G, Chen X, Cui N, et al. Aliment Pharmacol Ther 2015;42(10):1149-57. View abstract. Gut 2004;53:108-14. 2018;10(11). Int J Dermatol. Lactobacillus reuteri as a therapeutic agent in acute diarrhea in young children. A double-blind placebo-controlled randomized trial on probiotics in small bowel bacterial overgrowth in children treated with omeprazole. Pediatrics 2013;132(3):e666-76. Lu L, Walker WA. Czajeczny D, Kabzińska K, Wójciak RW. View abstract. Al Faleh K, Anabrees J. Probiotics for prevention of necrotizing enterocolitis in preterm infants. View abstract. View abstract. View abstract. Br J Nutr. View abstract. View abstract. Oksanen PJ, Salminen S, Saxelin M, et al. Nutr Res 2002;22:393-403. Early research in patients with genital herpes shows that applying lactobacillus in the vagina may reduce symptoms of genital herpes. Jones ML, Martoni CJ, Parent M, Prakash S. Cholesterol-lowering efficacy of a microencapsulated bile salt hydrolase-active Lactobacillus reuteri NCIMB 30242 yoghurt formulation in hypercholesterolaemic adults. 2020;9(3):305-310. Current and potential uses of probiotics. Parma M, Dindelli M, Caputo L, Redaelli A, Quaranta L, Candiani M. The role of vaginal Lactobacillus Rhamnosus (Normogin®) in preventing Bacterial Vaginosis in women with history of recurrences, undergoing surgical menopause: a prospective pilot study. [2] The primary colonizing bacteria of a healthy individual are of the genus Lactobacillus,[3] such as L. crispatus, and the lactic acid they produce is thought to protect against infection by pathogenic species. [28] demonstrated that cervicovaginal fluid and semen have a significant H2O2-blocking activity and they later [11] demonstrated that physiological concentrations of H2O2 below 100 μM View abstract. Eur J Pharm Biopharm 2000;50:389-95. [12] Lactobacillus species differ in premenopausal women, i.e. Suppressive effect of Lactobacillus gasseri OLL 2716 (LG21) on Helicobacter pylori infection in humans. J Infect Dis 1997;175:218-21. Cianci A, Cicinelli E, De Leo V, et al. Lin MY, Yen CL, Chen SH. [48][49], Parts of this article (those related to documentation) need to be. View abstract. View abstract. pii: E1761. Escherichia coli, Gardnerella vaginalis, Mobiluncus spp., Neisseria gonorrhoeae, Peptostreptococcus anaerobius, P. bivia and Staphylococcus aureus. Constipation. View abstract. View abstract. Effect of Lactobacillus reuteri on intestinal resistance to Cryptosporidium parvum infection in a murine model of acquired immunodeficiency syndrome. Hasslöf P, West CE, Videhult FK, Brandelius C, Stecksén-Blicks C. Early intervention with probiotic Lactobacillus paracasei F19 has no long-term effect on caries experience. Probiotics and gastrointestinal health. View abstract. Lancet. Szajewska H, Ruszczynski M, Kolacek S. Meta-analysis shows limited evidence for using Lactobacillus acidophilus LB to treat acute gastroenteritis in children. Fractures. J Gastrointestin Liver Dis. Early pregnancy probiotic supplementation with Lactobacillus rhamnosus HN001 may reduce the prevalence of gestational diabetes mellitus: a randomised controlled trial. Scand J Infect Dis. (check all that apply), What factors are most important to you? 2013;47(5):437-9. Infants born weighing less than 2500 grams (5 pounds, 8 ounces). 2017 Dec;29:e13145. View abstract. Kalliomaki M, Salminen S, Arvilommi H et al. Kato K, Funabashi N, Takaoka H, et al. View abstract. Venturi A, Gionchetti P, Rizzello F, et al. Cystic fibrosis. Tursi A, Brandimarte G, Giorgetti GM, et al. Effect of probiotic use on antibiotic administration among care home residents: A randomized clinical trial. Mimura T, Rizzello F, Helwig U, et al. 2014 24;13:75. Consumption of fermented and nonfermented dairy products: effects on cholesterol concentrations and metabolism. Studies have found that the consumption of sucralose decreases the number of anaerobic bacteria, lactobacilli and bifidobateria. Infections of the kidney, bladder, or urethra (urinary tract infections or UTIs). View abstract. To avoid this interaction take lactobacillus products at least 2 hours before or after antibiotics. Lactobacilli vs antibiotics to prevent urinary tract infections: a randomized, double-blind, noninferiority trial in postmenopausal women. View abstract. Arzneimittelforschung 1996;46:68-73. . View abstract. J Assoc Physicians India 2013;61(10):708-12. World J Gastroenterol. 2019;42(3):364-371. Cadieux P, Burton J, Gardiner G, et al. Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection: A Systematic Review With Meta-Regression Analysis. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. Infect Immun 1985;47:84-9. It's also possible that lactobacillus may be more beneficial when used along with other probiotics than when used as a single probiotic. 2014;30(4):189-94. 2017:1-10. View abstract. J Matern Fetal Neonatal Med. A randomized trial evaluating virus-specific effects of a combination probiotic in children with acute gastroenteritis. World Gastroenterology Organisation. Information from this source is evidence-based and objective, and without commercial influence. Early research also shows that taking lactobacillus and bifidobacterium short-term can improve symptoms in women with stomach pain. J Pediatr. Br J Nutr. In addition, the vagina is hypoxic most of the time, whereas lactobacilli require oxygen to produce hydrogen peroxide. Gerasimov SV, Ivantsiv VA, Bobryk LM, et al. Sex Transm Dis 1992;19:146-8.. View abstract. Arch Dis Child Fetal Neonatal Ed. Giving lactobacillus to infants and children seems to reduce the chance of upper airway infections. Kishi A, Uno K, Matsubara Y, et al. Nat Commun. View abstract. J Clin Pharm Ther 2008;33:663-8. View abstract. Probiotic use of lactobacilli in the human female urogenital tract. Int J Food Microbiol 1998;41:195-204. View abstract. Abrahamsson TR, Jakobsson T, Bottcher MF, et al. Husain S, Allotey J, Drymoussi Z, et al. Travelers' diarrhea is caused by bacteria, viruses, or parasites that the traveler has not been exposed to before. Pediatrics 2007;119:e124-30. Prebiotics and probiotics: are they functional foods? View abstract. Swelling (inflammation) and sores inside the mouth (oral mucositis). But one large study shows that lactobacillus does not reduce crying. Growth and development in premature infants. Gut 2002;51:405-9. [10][11], Low pH is generally accepted to be the main mechanism controlling the composition of the vaginal microflora. Sen S, Mullan MM, Parker TJ, et al. Nutr Cancer 1996;25:197-204. Shen NT, Maw A, Tmanova LL, et al. Cohen CR, Wierzbicki MR, French AL, et al. View abstract. Madsen KL, Doyle JS, Jewell LD, et al. Supplementation with two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, reduces fasting triglycerides and enhances apolipoprotein A-V levels in non-diabetic subjects with hypertriglyceridemia. Am J Gastroenterol 2000;95:1231-8.. View abstract. [18] In agreement with this, L. iners, most frequently associated with disturbed vaginal microflora,[23][24] is a poor producer of H2O2. Vaginal yeast infections. J Pediatr Gastroenterol Nutr 1997;24:399-404. Research shows that taking certain lactobacillus strains can prevent the development of allergic reactions, such as asthma, runny nose, and eczema, in infants with a. Overgrowth of bacteria in the vagina. However, research is inconsistent. Probiotics for the Primary and Secondary Prevention of C. difficile Infections: A Meta-analysis and Systematic Review. However, not all strains seem to work, and not all studies agree. But taking lactobacillus capsules does not seem to prevent bacteria overgrowth in the vagina in pregnant women. Antibiotics usually cause a short-term decline in beneficial bacteria, such as Bifidobacteria and Lactobacilli, and can temporarily increase harmful bacteria like Clostridium . Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. View abstract. Br J Nutr. View abstract. View abstract. 2016 Apr;70(4):463-9. BMC Gastroenterol. Diarrhea in people taking antibiotics (antibiotic-associated diarrhea). 2018 Aug 9;10(8). 2019;13(1):175-182. But other research shows that drinking a milk product containing lactobacillus reduces symptoms of lactose intolerance. Sharma A, Rath GK, Chaudhary SP, Thakar A, Mohanti BK, Bahadur S. A trial of adding Lactobacillus johnsonii EM1 to levocetirizine for treatment of perennial allergic rhinitis in children aged 7-12 years. Fuentes MC, Lajo T, Carrión JM, Cuñé J. All rights reserved. 2018 Jun;57(6):635-641. View abstract. Competitive exclusion of uropathogens from human uroepithelial cells by Lactobacillus whole cells and cell wall fragments. Zamani B, Golkar HR, Farshbaf S, et al. Probiotics for the prevention of antibiotic-associated diarrhea in children. Appl Physiol Nutr Metab. pii: E887. Pelto L, Ioslauri E, Lilius EM, et al. View abstract. J Infect 1996;32:165-7. [25][26] Vaginal colonization by H2O2-producing lactobacilli has been associated with a decrease in the occurrence of bacterial vaginosis (BV). View abstract. 2018;107(12):2172-2178. View abstract. Prospective, randomized, open-label trial comparing the safety, efficacy, and tolerability of an acne treatment regimen with and without a probiotic supplement and minocycline in subjects with mild to moderate acne. Early research shows that taking lactobacillus reduces stress and sleep problems in students preparing for exams. Dall LB, Lausch KR, Gedebjerg A, Fuursted K, Storgaard M, Larsen CS. View abstract. Zhao M, Shen C, Ma L. Treatment efficacy of probiotics on atopic dermatitis, zooming in on infants: a systematic review and meta-analysis. [12] with inhibitory activity View abstract. But other research has found no benefit in people with this condition. O'Mahony L, McCarthy J, Kelly P, et al. Atherosclerosis. 2017;12(12):e0189141. Goldin BR. A randomized clinical trial. View abstract. Michael DR, Jack AA, Masetti G, et al. Mayo Clin Proc 2001;76:883-9. View abstract. Diarrhea caused by rotavirus. Taking 2 billion colony-forming units of lactobacillus daily for 5 weeks can improve quality of life by almost 18% in people with grass. Effect of oral supplementation of lactobacilli on bacterial translocation in acute liver injury induced by D-galactosamine. Effect of probiotic Lactobacillus strains in young children hospitalized with acute diarrhea. Evans M, Salewski RP, Christman MC, Girard SA, Tompkins TA. Treatment of recurrent Clostridium difficile colitis with Lactobacillus GG. Gastroenterology 1999;116:1107-14. View abstract. Dig Dis Sci 1998;43:133-7. Diabetes Care. Palmfeldt J, Hahn-Hagerdal B. Reid G, Bruce AW, Taylor M. Influence of three-day antimicrobial therapy and lactobacillus vaginal suppositories on recurrence of urinary tract infections. Coccorullo P, Strisciuglio C, Martinelli M, Miele E, Greco L, Staiano A. Lactobacillus reuteri (DSM 17938) in infants with functional chronic constipation: a double-blind, randomized, placebo-controlled study. Some research shows that drinking milk with lactobacillus still causes symptoms, like gas, in people with lactose intolerance. Nutritional and therapeutic aspects of lactobacilli. Antibiotics (Basel). Clinical and metabolic response to probiotic supplementation in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial. View abstract. Zhang J, Ma S, Wu S, Guo C, Long S, Tan H. Effects of Probiotic Supplement in Pregnant Women with Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. View abstract. A Taxonomic Note on the Genus Lactobacillus: Description of 23 Novel Genera, Emended Description of the Genus Lactobacillus Beijerinck 1901, and Union of Lactobacillaceae and Leuconostocaceae. Guarino A, Canani RB, Spagnuolo MI, et al. View abstract. Scand J Gastroenterol 2013;48(10):1127-35. The abstract can be read here while the full review can be read by clicking the following link. Beausoleil, M., Fortier, N., Guenette, S., L'ecuyer, A., Savoie, M., Franco, M., Lachaine, J., and Weiss, K. Effect of a fermented milk combining Lactobacillus acidophilus Cl1285 and Lactobacillus casei in the prevention of antibiotic-associated diarrhea: a randomized, double-blind, placebo-controlled trial. This usually reduces pathogens from infecting to the vaginal epithelium. Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children. Ineffectiveness of probiotics in preventing recurrence after curative resection for Crohn's disease: a randomised controlled trial with Lactobacillus GG. Early research in pregnant women shows that taking lactobacillus reduces breast tissue swelling involving an infection. View abstract. Also, more research is needed to determine if lactobacillus has different effects in children who have been given rotavirus vaccine compared with those who have not. View abstract. 1996;28(6):615-9. 2012;66(11):1234-41. This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. View abstract. This survey is being conducted by the WebMD marketing sciences department. View abstract. Luoto R, Matomäki J, Isolauri E, Lehtonen L. Incidence of necrotizing enterocolitis in very-low-birth-weight infants related to the use of Lactobacillus GG. Inflamm Bowel Dis. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Maggi L, Mastromarino P, Macchia S, et al. The most well-studied strain of lactobacillus seems to reduce the chance of diarrhea by about 60% to 70% when started within 2 days of beginning antibiotic treatment and continued for at least 3 days after finishing the antibiotics. View abstract. View abstract. Bibiloni R, Fedorak RN, Tannock GW, et al. Infect Immun 1989;57:2447-51. Ann Med 1990;22:53-6.. View abstract. Examination of strains of lactobacilli for properties that may influence bacterial interference in the urinary tract. Ann Med 2015;47(6):430-40. Infection of the airways. View abstract. Petruzziello C, Migneco A, Cardone S, et al. Int J Food Microbiol 2000;55:235-8. VSL#3 probiotic-mixture induces remission in patients with active ulcerative colitis. Influence of culture pH on survival of Lactobacillus reuteri subjected to freeze-drying. Alander M, Satokari R, Korpela R, et al. Cohen SH, Gerding DN, Johnson S, et al. Morita Y, Jounai K, Miyake M, Inaba M, Kanauchi O. Probiotics for the prevention of Clostridium difficile-associated diarrhea. Reduced or blocked flow of bile from the liver (cholestasis). Probiotic bacteria down-regulate the milk-induced inflammatory response in milk-hypersensitive subjects but have an immunostimulatory effect in healthy subjects. Am J Clin Nutr 2000;71:674-81. Excessive growth of bacteria in the small intestines. Khalili L, Alipour B, Asghari Jafar-Abadi M, et al. 2017 Infectious Diseases Society of America Clinical Practice Guidelines for the Diagnosis and Management of Infectious Diarrhea. fail to inactivate any of the 17 tested BV-associated bacteria, e.g. Felley CP, Corthesy-Theulaz I, Blanco Rivero JL, et al. Medicina (B Aires). View abstract. O'Sullivan MA, O'Morain CA. Preston K, Krumian R, Hattner J, de Montigny D, Stewart M, Gaddam S. Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R and Lactobacillus rhamnosus CLR2 improve quality-of-life and IBS symptoms: a double-blind, randomised, placebo-controlled study. Taking lactobacillus starting at the beginning of the. View abstract. Xu M, Wang J, Wang N, Sun F, Wang L, Liu XH. Linn YH, Thu KK, Win NHH. World J Gastroenterol. 2014 Jul;59(1):132-52. It is also remarkable that catalase, which provides bacteria protection against toxic H2O2, is absent in lactobacilli,[18][29] and as such they would be unprotected against their own H2O2 production. Open Forum Infect Dis 2017;4(2):ofx085. 12 The presence of these has been positively associated with being white, aged over 20 years, using barrier contraception, and low frequency of BV and gonorrhoea. View abstract. Efficacy of Lactobacillus rhamnosus GG in treatment of acute pediatric diarrhea: A systematic review with meta-analysis. A small clinical study in children with asthma shows that taking lactobacillus slightly reduces asthma severity and increases asthma control. Preventive effect of Bifidobacterium supplementation on neonatal cholestasis in preterm neonates with very low birth weight. Pathologic and physiologic interactions of bacteria with the gastrointestinal epithelium. J Allergy Clin Immunol 1997;99:179-85. . Lee C, Wongjarupong N, Narayan M, Melzer AC. Cholesterol-lowering efficacy of Lactobacillus plantarum CECT 7527, 7528 and 7529 in hypercholesterolaemic adults Br J Nutr 2013;109(10):1866-72. nov. and Lactobacillus johnsonii sp. nov. and synonymy of Lactobacillus acidophilus group A3 (Johnson et al. Sheih YH, Chiang BL, Wang LH, et al. View abstract. Probiotics for the Prevention of Gestational Diabetes Mellitus in Overweight and Obese Women: Findings From the SPRING Double-Blind Randomized Controlled Trial. Pediatr Infect Dis J 2002;21:417-9. View abstract. Response of patients with irritable bowel syndrome and lactase deficiency using unfermented acidophilus milk. Some of the obligate and facultative anaerobic bacteria are associated with BV. mucositis in patients with head and neck cancer: a randomized double-blind placebo-controlled study. Early research shows that taking a lactobacillus lozenge doesn't improve gum health in people with this condition. View abstract. [3] Since the first description of lactobacilli by Döderlein, lactobacilli have been generally considered the gatekeepers of the vaginal ecosystem.

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